I made a thread about this issue here: http://electro-music.com/forum/viewtopic.php?t=31032 . Kassen suggested that I send an email here, thinking that this might require some insight into RTAudio (not sure myself what it is). My Motu Ultralite runs ChucK applications perfectly, as long as I don't bother configuring audio channels, making do with having sound output only coming at the main outputs, and sound input from the MacBook Pro's built-in input or microphone. The problems start when I try to route to other outputs or want to use the Ultralite's inputs. After a bit of trial-and-error, I managed to get ChucK to do what I want to do (more or less) by using this command line to start the program: chuck --adc4 --in8 --out8 test.ck Here's the test code I have been using: adc.chan(6) => dac.chan(0); adc.chan(7) => dac.chan(1); while (true) { 1::day => now; } This will route audio from inputs 7 and 8 to outputs 1 and 2 (not the main outputs - if I want to hear the sound from the ChucK app I need to physically connect the 1 and 2 output to another input on the sound interface). A curious thing here is that if I start like this instead: chuck --adc4 --in8 --out6 test.ck // 6 outputs instead of 8 I get a mangled sound (sounding a bit like a sample rate or bandwidth mismatch - check the sound sample that I attached at the electro-music.comthread), and rather than just coming out of outputs 1 and 2 (as they do when I use the previous command line), the sound appears at all eight analog outputs on the Ultralite (according to the hardware meters on the Motu). If I try --out4 I get sound on outputs 1,2,,5,6,7, and 8. Another thing: if I leave out the output option altogether (i.e. take away "--out8"), I get a mangled sound as before, but only on the main output. I've also seen stuff like getting sound on every second output (1,3,5,7) for some option, though I can't seem to reproduce that now. I think I can work with what happens on my first example, but I'm still a bit curious as to what is going on with these options, and why --out6 causes the sound to behave radically different from --out8. I've checked my drivers - the Ultralite firmware is up to date and I think the OSX drivers are too. I'm running ChucK 1.2.1.2. I might have to leave my Motu for a week, so i might not be able to test stuff right away, if anyone comes up with something. /Stefan -- Release me, insect, or I will destroy the Cosmos!