March 2025 - talks - lists.cs.princeton.edu

AI Lab Distinguished Lecture, Professor Eric Xing, TODAY March 7th
by Emily C. Lawrence 07 Mar '25

07 Mar '25

Please join us TODAY for our Distinguished Lecture Series: Eric Xing , President of Mohamed bin Zayed University of Artificial Intelligence, Professor of Computer Science at Carnegie Mellon University, Founder of Petuum Inc., and Co-Founder & Chief Scientist of GenBio AI 2-3:30 p.m., TODAY, March 7, 2025 Maeder Auditorium Reception after the talk [ https://docs.google.com/forms/d/e/1FAIpQLScAuQM_UOPkXY0psLTfHmth8XQSUJCexw4… | RSVP ] Professor Eric P. Xing is the President of the Mohamed bin Zayed University of Artificial Intelligence, Professor of Computer Science at Carnegie Mellon University, Founder of Petuum Inc., and Co-Founder & Chief Scientist of GenBio AI His main research interests are the development of machine learning and statistical methodology, and large-scale computational system and architectures, for solving problems involving automated learning, reasoning, and decision-making in artificial, biological, and social systems. Prof. Xing has served on the editorial boards of leading scientific journals including the Journal of the American Statistical Association, Annals of Applied Statistics, PLOS Journal of Computational Biology, IEEE Journal of Pattern Analysis and Machine Intelligence, Machine Learning Journal, and Journal of Machine Learning Research. He was elected Fellows AAAI, ACM, ASA, IEEE, and IMS. Talk Title: “Toward AI-Driven Digital Organism: Multiscale Foundation Models for Predicting, Simulating, and Programming Biology at All Levels” Abstract : At the core of medicine, pharmacy, public health, longevity, agriculture, and environment, is biology at work. Biology in the physical world is too complex to manipulate and always expensive and risky to tamper with. In this talk, I present a vision of using AI to model and simulate biology and life. I will layout an engineering viable approach to construct an AI-Driven Digital Organism (AIDO), leveraging self-supervised pretraining and adaption of large-scale foundation models, and I introduce some early results including 5 SOTA foundation models for DNA, RNA, Protein, Structure, and Single Cell, respectively, and their abilities to tackle biological problems at the full spectrum of granularities, from sequence, to structure, to network, to phenotype, to diseases, and to drug responses. We envision that AIDO opens up a safe, affordable and high-throughput alternative platform for predicting, simulating and programming biology at all levels from molecules to cells to individuals, and is poised to trigger a new wave of better-guided wet-lab experimentation and better-informed first-principle reasoning, which can eventually help us better decode and improve life. [ https://invent.ai.princeton.edu/about/get-involved | AI² Mailing List ] [ https://invent.ai.princeton.edu/about/get-involved | Get Involved ] We are rapidly developing AI for Accelerated Invention activities and programs. Sign up for the mailing list and reach out to us with your questions.

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AI Lab Distinguished Lecture Series: Eric Xing- RSVP!
by Emily C. Lawrence 06 Mar '25

06 Mar '25

We invite you to attend the AI Lab’s upcoming Distinguished Lecture Series, with the first event being held on March 7, 2025. Distinguished Lecture Series Eric Xing, Professor and President of Mohamed bin Zayed University of Artificial Intelligence March 7, 2025 2pm-3:30pm Maeder Auditorium [ https://docs.google.com/forms/d/e/1FAIpQLScAuQM_UOPkXY0psLTfHmth8XQSUJCexw4… | RSVP ] Talk Title: Toward AI-Driven Digital Organism: Multiscale Foundation Models for Predicting, Simulating, and Programming Biology at All Levels Abstract: At the core of medicine, pharmacy, public health, longevity, agriculture, and environment, is biology at work. Biology in the physical world is too complex to manipulate and always expensive and risky to tamper with. In this talk, I present a vision of using AI to model and simulate biology and life. I will layout an engineering viable approach to construct an AI-Driven Digital Organism (AIDO), leveraging self-supervised pretraining and adaption of large-scale foundation models, and I introduce some early results including 5 SOTA foundation models for DNA, RNA, Protein, Structure, and Single Cell, respectively, and their abilities to tackle biological problems at the full spectrum of granularities, from sequence, to structure, to network, to phenotype, to diseases, and to drug responses. We envision that AIDO opens up a safe, affordable and high-throughput alternative platform for predicting, simulating and programming biology at all levels from molecules to cells to individuals, and is poised to trigger a new wave of better-guided wet-lab experimentation and better-informed first-principle reasoning, which can eventually help us better decode and improve life. Gina Palmisano Office and Events Coordinator Princeton Laboratory for Artificial Intelligence (AI Lab)

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CS Colloquium speakers: week of February 26
by Emily C. Lawrence 06 Mar '25

06 Mar '25

CS Colloquium speakers Speaker: Jialin Ding, Amazon Web Services Date: Monday, February 26 Time: 12:30pm EST Location: CS 105 Host: Wyatt Lloyd Event page: https://www.cs.princeton.edu/events/26578 Register for live-stream online here: https://princeton.zoom.us/webinar/register/WN_10z_l8MYRr21ZOuPqA8Odw Title: Instance-Optimization: Rethinking Database Design for the Next 1000X Abstract: Modern database systems aim to support a large class of different use cases while simultaneously achieving high performance. However, as a result of their generality, databases often achieve adequate performance for the average use case but do not achieve the best performance for any individual use case. In this talk, I will describe my work on designing databases that use machine learning and optimization techniques to automatically achieve performance much closer to the optimal for each individual use case. In particular, I will present my work on instance-optimized database storage layouts, in which the co-design of data structures and optimization policies improves query performance in analytic databases by orders of magnitude. I will highlight how these instance-optimized data layouts address various challenges posed by real-world database workloads and how I implemented and deployed them in production within Amazon Redshift, a widely-used commercial database system. Bio: Jialin Ding is an Applied Scientist at AWS. Before that, he received his PhD in computer science from MIT, advised by Tim Kraska. He works broadly on applying machine learning and optimization techniques to improve data management systems, with a focus on building databases that automatically self-optimize to achieve high performance for any specific application. His work has appeared in top conferences such as SIGMOD, VLDB, and CIDR, and has been recognized by a Meta Research PhD Fellowship. To learn more about Jialin’s work, please visit [ https://jialinding.github.io/ | https://jialinding.github.io/ ] . CSML/CS/PSY Colloquium Speaker: Brenden Lake, New York University Date: Tuesday, February 27 Time: 12:30pm EST Location: CS 105 Host: Tom Griffiths Event page: https://csml.princeton.edu/events/csmlpsycs-seminar Register for live-stream online here: https://princeton.zoom.us/webinar/register/WN_aUfLfVQFSIqV2RDSYu4big Title: Towards more human-like learning in machines: Bridging the data and generalization gaps Abstract: There is an enormous data gap between how AI systems and children learn: The best LLMs now learn language from text with a word count in the trillions, whereas it would take a child roughly 100K years to reach those numbers through speech (Frank, 2023, "Bridging the data gap"). There is also a clear generalization gap: whereas machines struggle with systematic generalization, children can excel. For instance, once a child learns how to "skip," they immediately know how to "skip twice" or "skip around the room with their hands up" due to their compositional skills. In this talk, I'll describe two case studies in addressing these gaps. 1) The data gap: We train deep neural networks from scratch (using DINO, CLIP, etc.), not on large-scale data from the web, but through the eyes and ears of a single child. Using head-mounted video recordings from a child as training data (<200 hours of video slices over 26 months), we show how deep neural networks can perform challenging visual tasks, acquire many word-referent mappings, generalize to novel visual referents, and achieve multi-modal alignment. Our results demonstrate how today's AI models are capable of learning key aspects of children's early knowledge from realistic input. 2) The generalization gap: Can neural networks capture human-like systematic generalization? We address a 35-year-old debate catalyzed by Fodor and Pylyshyn's classic article, which argued that standard neural networks are not viable models of the mind because they lack systematic compositionality -- the algebraic ability to understand and produce novel combinations from known components. We'll show how neural networks can achieve human-like systematic generalization when trained through meta-learning for compositionality (MLC), a new method for optimizing the compositional skills of neural networks through practice. With MLC, neural networks can match human performance and solve several machine learning benchmarks. Given these findings, we'll discuss the paths forward for building machines that learn, generalize, and interact in more human-like ways based on more natural input. Related articles: Vong, W. K., Wang, W., Orhan, A. E., and Lake, B. M (2024). Grounded language acquisition through the eyes and ears of a single child. Science, 383, 504-511. Orhan, A. E., and Lake, B. M. (in press). Learning high-level visual representations from a child’s perspective without strong inductive biases. Nature Machine Intelligence. Lake, B. M. and Baroni, M. (2023). Human-like systematic generalization through a meta-learning neural network. Nature, 623, 115-121. Bio: Brenden M. Lake is an Assistant Professor of Data Science and Psychology at New York University. He received his M.S. and B.S. in Symbolic Systems from Stanford University in 2009, and his Ph.D. in Cognitive Science from MIT in 2014. He was a postdoctoral Data Science Fellow at NYU from 2014-2017. Brenden is a recipient of the Robert J. Glushko Prize for Outstanding Doctoral Dissertation in Cognitive Science and the MIT Technology Review 35 Innovators Under 35. His research was also selected by Scientific American as one of the 10 most important advances of 2016. Brenden's research focuses on computational problems that are easier for people than they are for machines, such as learning new concepts from just a few examples, learning by asking questions, learning by generating new goals, and learning by producing novel combinations of known components. CS Colloquium Speaker: Eric Mitchell, Stanford University Date: Thursday, February 29 Time: 12:30pm EST Location: CS 105 Host: Karthik Narasimhan Event page: https://www.cs.princeton.edu/events/26587 Register for live-stream online here: TBA Talk info TBA

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AI² Research Talk Series - Join Us! TODAY, March 5th, 2025: “Generative AI for Functional Protein Design” with Lei Li
by Emily C. Lawrence 05 Mar '25

05 Mar '25

Please join us: 4:30 p.m., TODAY, March 5th AI² Research Talk Series Bendheim House, Classroom 103 Lei Li is an Assistant Professor in Language Technologies Institute at Carnegie Mellon University. His research focuses on machine translation, agentic LLM, AI security, and AI-powered drug discovery. He received Ph.D. from CMU School of Computer Science in 2011. He is a recipient of the ACL 2021 Best Paper Award and the 2012 ACM SIGKDD dissertation award (runner-up), and is recognized as Notable Area Chair of the ICLR 2023. Previously, he was an associate professor (tenured) at UC Santa Barbara, the Founding Director of ByteDance AI Lab, a principal scientist at Baidu, and a postdoc researcher at UC Berkeley. He developed key technologies deployed in VolcTrans, Xiaomingbot, and TikTok, serving over a billion users. Web: [ https://www.cs.cmu.edu/~leili/ | https://www.cs.cmu.edu/~leili/ ] “Generative AI for Functional Protein Design” Abstract: Generative AI is not only revolutionizing language processing but is also transforming scientific fields such as biology and chemistry, as exemplified by the 2024 Nobel Prize in Chemistry. In this talk, we explore three paradigms for functional protein design: sequence-based, geometry-based, and sequence/structure co-design. We introduce three advanced generative AI models following these paradigms—IsEMPro, SurfPro, and EnzyGen—along with their sample-efficient learning methodologies. Additionally, we highlight four impactful applications: designing enzymes with biocatalytic functions, optimizing proteins for specific fitness goals, developing protein-protein binders, and creating antimicrobial peptides. By emphasizing the powerful synergies between AI and molecular sciences, this talk seeks to inspire collaboration and drive advancements at the forefront of drug discovery, material innovation, and sustainable chemical manufacturing. [ https://invent.ai.princeton.edu/about/get-involved | AI² Mailing List ] [ https://invent.ai.princeton.edu/about/get-involved | Get Involved ] We are rapidly developing AI for Accelerated Invention activities and programs. Sign up for the mailing list and reach out to us with your questions.

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