Our next talk in the PPH seminar series is on Friday, February 6, at 12 pm , at 252 Nassau Street. Sneha Goenka will present, "Biology Needs Computer Architects: Keeping Up with Genomic-scale Data. " Professor Sneha Goenka is an Assistant Professor in the ECE department at Princeton University. Lunch will be provided. Abstract: The landscape of computing has undergone a significant transformation with the death of Dennard scaling and the slowing of Moore’s law: applications now drive innovations in computer systems architecture. At the same time, the advent of high throughput, low-cost sequencing technology has revolutionized genomics. The massive amount of data generated in genomics has uncovered acute compute challenges in biological inference due to limitations of software on traditional multi-core systems. To address this challenge, my research employs a hardware-software-algorithm co-design approach to significantly improve computational performance in key areas of comparative and clinical genomics. In this talk, I will present systems that accelerate pipelines in both these domains of genomics. First, I will present Darwin-WGA (FPGA/ASIC) and SegAlign (GPU) for cross-species whole genome alignment where co-design has yielded orders of magnitude increase in speed. Additionally, there are gains in accuracy while modifying the algorithm to improve the underlying hardware implementation. Next, I will talk about the ultra-rapid nanopore whole genome sequencing pipeline that can deliver a genetic diagnosis in under 8 hours, making it the fastest pipeline to date. The scalable, cloud-based distributed infrastructure overcomes system bottlenecks to enable near real-time computation and improved variant identification. This pipeline has been deployed in critical care units in Stanford hospitals and applied to 25 patients. Finally, I will share my vision and our current work on the continued advancements in computer systems applied to emerging fields such as pangenomics, single cell genomics, cancer and long read clinical sequencing. Upcoming talks include the following - please check our [ https://us.list-manage.com/fbV_-3DQ__6?e=691aac62ef&c2id=f584458f8dee0f3191b5ca62c8d25736 | website ] for more information and updates! Monday, Feb 9, at 10:00 am **NOTE THE SPECIAL DATE AND TIME** Stephany Duda (Vanderbilt) [ https://us.list-manage.com/x7_GHnGq-1c?e=691aac62ef&c2id=f584458f8dee0f3191b5ca62c8d25736 | Beyond Data Collection: REDCap as a Platform for Research Collaboration ] Friday, Feb 27, Aayush Visaria (Rutgers Robert Wood Johnson Medical School) ** AI and Precision Health series ** AI and Precision Health: [ https://us.list-manage.com/6_L2WELiCM8?e=691aac62ef&c2id=f584458f8dee0f3191b5ca62c8d25736 | Beyond Fat Mass: How Adiposity, Oxidative Stress, and Bilirubin Shape Metabolic Risk ] Friday, March 6, Florencia Torche (Princeton): [ https://us.list-manage.com/JR1vCff5h6C?e=691aac62ef&c2id=f584458f8dee0f3191b5ca62c8d25736 | Early Life Exposures and Social Inequality ] Friday, March 20, Ricky Bloomfield (Oura) ** AI and Precision Health series ** [ https://us.list-manage.com/_rvWqr__Bca?e=691aac62ef&c2id=f584458f8dee0f3191b5ca62c8d25736 | AI and Precision Health: From Episodic Care to Continuous Health: How Wearables and AI Are Reshaping Preventive Care ] Friday, April 3, David Pagliaccio (Columbia) Friday, April 10, René Vidal (UPenn) ** AI and Precision Health series ** Friday, April 24, Tom Silver (Princeton) Friday, May 8, Jessica Hamilton (Rutgers) [ https://us.list-manage.com/QW-l0J1AO1x?e=691aac62ef&c2id=f584458f8dee0f3191b5ca62c8d25736 | View all upcoming PPH events ] . Please note that getting to the seminar space at 252 Nassau Street currently requires that you climb a set of stairs. If an accommodation is needed, please contact PPH in advance at: [ mailto:princetonPPH@princeton.edu | princetonPPH@princeton.edu ] Thank you, Princeton Precision Health