Please join the Princeton Precision Health (PPH) Initiative for the next talk of our spring semester series on Friday, March 28 , at 12:00 pm , at 252 Nassau Street. Matt Salganik (Princeton University) and Mark Verhagen (Oxford University) National population registries, large language models, and precision health This talk will present our interdisciplinary, international collaboration exploring the genetic, social, and environmental factors shaping human health. Our approach leverages two innovations: 1) secure access to the Netherlands’ complete population registries within a high-performance computing environment, and 2) open-weight large language models (LLMs). We’ll share our journey from award-winning LLM-based predictive modeling with Dutch registry data to our current work fusing these government records with the Netherlands Twin Registry. This fusion aims to create the world’s largest twin study with comprehensive health information, enabling 1) high-throughput heritability estimates across various health conditions and 2) estimates of the social and environmental contributions to disease by studying identical twins who have different health outcomes. Looking ahead, we plan to incorporate genetic and other “omic” data from 150,000 people to further clarify genetic contributions. Our work operates within a robust ethical and legal framework, which helps foster diverse and growing collaborations across disciplines. Supported in part by the New Jersey Alliance for Clinical and Translational Science. Lunch will be provided. Please note that getting to the seminar space currently requires that you climb a set of stairs. If an accommodation is needed, please contact PPH in advance at: [ mailto:princetonPPH@princeton.edu | princetonPPH@princeton.edu ] Check out our website for our full speaker lineup: [ https://pph.princeton.edu/events | https://pph.princeton.edu/events ]